Issue N# 1 - 1999
LARYNGOLOGY
The adenocarcinoma of the larynx : in aim of a clinic case. Histologic, immuno-histochemestry and electron microscope studies
Authors : S. Incandela, F. Aragona, G. Di Marco (Palermo)
Ref. : Rev Laryngol Otol Rhinol 1999;120,1:35-38.
Article published in english 
Summary :
Adenocarcinoma "not otherwise specified" of the larynx appears to be extremely rare. We report a case of adenocarcinoma "nos" arising in the larynx of a 72 year-old white man. The neoplasia was Alcian and Pas negative. Immunohistochemical studies revealed negative immunoreactivity from NSE, chromogranins and S100 ; cytokeratin was positive. Electron microscopy revealed electrodense granules of varying sizes, but with no obvious central core surrounded by a limiting membrane. The patient underwent a total laryngectomy and functional neck dissection, with mandibular extension. And he is free of tumor after 4 years postoperatively.
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